Jin Zhou received the Ph.D. degree from the Beijing Institute of Basic Medical Sciences in 2010. She got the National Science Fund for outstanding Young Scholars support in 2016. She became Beijing Science and Technology Star in 2017 and young scholars of Chinese Institute for Brain Research in 2020. Her research interests include tissue engineering and regenerative medicine. The main research direction include: 1) From the view of material biology and epigenetics, she deeply clarified the mechanism of biomaterial regulate cell differentiation, transdifferentiation and dedifferentiation. 2) Biomimetic construction of engineered cardiac tissue and myocardial infraction repair. 3) Research on heart regeneration based on microenvironment regulation biomaterials. As the project leader, she has undertaken more than 20 national and military projects and published more than 70 SCI papers such as Adv Mate, Adv Sci, Signal Transduct tar, ACS Nano, Nano Today, 26 national invention patents have been authorized, and 12 soft works have been published.

Topic title: Bionic construction of engineered cardiac tissue and heart regeneration research

Abstract:

Ischemic heart disease is one of the leading causes of death worldwide, with high clinical morbidity and mortality. Tissue engineering strategies based on nanomaterials and stem cells, as a potential therapeutic approach, provide a new therapeutic approach for the repair of damaged myocardium. Based on this, our team carried out a series of in vitro construction and myocardial infarction treatment and repair studies based on stem cells and nanomaterials, systematically clarified the basic principle of material regulation of myocardial development and remodeling, opened up a new way of myocardial tissue construction and myocardial infarction treatment based on conductive materials, and proposed a new strategy for heart regeneration based on microenvironment active regulation materials. It mainly includes: 1) Carrying out research on key technologies of engineering cardiac tissue construction based on natural extracellular matrix materials, and deeply clarifying the rules and mechanisms of biomaterial regulation of cell differentiation, dedifferentiation and transdifferentiation. 2) The research on myocardial patch construction and myocardial infarction repair based on new conductive materials such as carbon-based, conductive polymers and ionic conductivity has been carried out, revealing the basic principle of conductive nanomaterials regulating myocardial cell development and assembly, and improving the myocardial infarction treatment effect of conductive ECTs. 3) Considering the microenvironment characteristics such as inflammation, necrosis and ischemia in the early stage of myocardial infarction, our team developed intelligent response and active positive regulation hydrogel scaffold with anti-inflammatory, anti-oxidation and angiogenesis promotion effects. Through targeted on-demand delivery of functional nanoparticles and plasmids, effective regulation of anti-inflammatory, anti-oxidation, angiogenesis promotion and electrostimulation integration of myocardial infarction microenvironment was realized, and cardiac regeneration and repair ability were greatly improved. In the future, biomimetic scaffolds with active microenvironment regulation will play an important role in myocardial construction and heart regeneration.