Dr. Chengtie Wu, is the professor in Shanghai Institute of Ceramics, Chinese Academy of Sciences, and Director of the Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences. Prof. Wu is mainly engaged in the research of biomedical materials and implantable medical devices, and has won the National Fund for Outstanding Young Scholars, the leader of the Ten Thousand Talents Program, the national overseas high-level talents (youth) and the Humboldt scholars. He undertakes the key research and development Program of the 13th and 14th Five-Year Plan of the Ministry of Science and Technology, the 863 Program of the 12th Five-Year Plan, the key projects of the National Natural Science Fund and the Sino-German international cooperation and other scientific research projects. He is currently the associate editor of the academic journal "Applied Materials Today", associate editor of "Microstructure", and the editorial board member of “Acta Biomaterials” and “Bioactive Materials”. He edited a CRC English monograph and participated in the writing of 11 chapters of the English monograph. More than 300 SCI papers have been published in internationally famous journals such as Materials Today, Advanced Materials, Science Advances, Biomaterials, with H index 88 (Web of Science search). They have been selected as 2% of the world's top scientists. They have been selected by Elsevier in the list of highly cited scholars in China from 2015 to 2022 for eight consecutive years. A total of 70 patents have been applied for, and 30 Chinese patents and 2 American patents have been granted, of which 25 patented technologies have been transferred to the company. It won the JMC - Lectureship Award of the Royal Society of Chemistry (only one in the world in 2015), the IUMRS Young Scientists Award of the International Materials Association, the Outstanding Young Scientist Award of the Chinese Biomaterials Society, the Young Scientist Award of the Chinese Ceramics Society, the First Prize of Science and Technology of the Chinese Biomaterials Society.

Topic title: 3D Printing of Biomimetic Biomaterials

Abstract:

3D printing technology is one of the most promising technologies in the fields of tissue engineering and regenerative medicine, which can stack multiple components (materials, cells, etc.) layer by layer in three-dimensional space to construct complex and accurate structures. Therefore, for the construction of tissue regeneration scaffolds, 3D printing methods have far surpassed other traditional manufacturing methods. How to construct personalized tissue regeneration scaffolds with different compositions, structures, and functions through smart design and 3D printing technology is a research focus in the field of regenerative medicine. We have conducted a series of research work to meet the needs of biomimetic and functional 3D printing scaffolds, from material design, structural regulation, functional modification, and multi cell printing of artificial tissues. We have developed various 3D printing tissue regeneration scaffolds with excellent biological functions. Firstly, we prepared a series of biomimetic scaffolds with excellent tissue repair performance by regulating the macro/micro structure of 3D printed scaffolds. Macroscopically, through precise model design, printing out scaffolds with biomimetic lotus root and natural bone multi-level structures can effectively promote vascularized bone regeneration. At the micro level, by combining microbial catalysis and other technologies with 3D printing technology, a 3D printed scaffold with a specific micro nano structure is constructed, significantly improving the osteogenic performance of the scaffold. For tissue defects caused by diseases, scaffolds with a single repair function cannot achieve the ideal treatment goals. Therefore, we further combined 3D printing technology with surface modification strategies to develop various 3D printing scaffolds with dual functions of tumor treatment and tissue regeneration, thereby more efficiently curing defects caused by tumor diseases. In addition, for the regeneration and construction of complex tissues/organs, it is necessary to develop biomimetic scaffolds with a regular arrangement of multiple cells. Therefore, we further extend 3D material printing to 3D multicellular printing, by regulating the composition of inorganic bioinks, designing cell spatial distribution, and constructing multicellular scaffolds that simulate different complex tissues. The multicellular scaffold constructed through 3D cell printing has excellent tissue regeneration function both in vivo and in vitro, which offers a foundation for the three-dimensional reconstruction of other complex tissues/organs.