Weng Jie is a second level professor and doctoral supervisor at Southwest Jiaotong University (State Council Special Allowance Expert, Fellow of International Uion of Societies for Biomaterials Science and Engineering, First session fellow of China Society for Biological Materials, Cross century talent of the Ministry of Education). Selected for the World's Top 2% Scientists 2023 list. Engaged in the field of biomedical materials for a long-term time, involving bioceramics and nanomaterials, composite materials, surface modification of implants, drug release systems, tissue regeneration medicine, etc. Published over 310 SCI journal papers, with an H-index of 48 and more than 30 national invention patents, and was invited to give invitation presentations at academic conferences both domestically and internationally dozens of times. Won 1 second prize of National Science and Technology Progress Award, 3 first and second prizes each for provincial and ministerial level science and technology awards. The current member of the council and chairman of the Biomaterials Branch of the Chinese Society of Biomedical Engineering, executive member of the council and deputy chairman of the Bioceramics Branch of the Chinese Society of Biomedical Materials, and vice chairman of the Sichuan Society of Biomedical Engineering.

Topic title：Construction of pore diversity in tissue engineering scaffolds and its regulation of bone tissue regeneration

Abstract：

Osteoinduction of biomaterial scaffolds is a special phenomenon of ectopic bone regeneration typically found in porous scaffolds of biomaterials related to calcium phosphate components. It provides an approach to utilize the factors of biomaterial significance to activate the regenerative repair of the tissue itself without any exogenous growth factors. In present research, tissue engineering scaffolds with pore diversity characteristics were constructed by accumulating spherical granules and sugar spheres-leaching process. The relationship between architectural characteristics and ectopic bone formation were investigated by controlling macro-pore shape and size, interconnectivity, pore distribution and surface topography, so as to optimize the porous architectural characteristics of scaffolds, which are critical to cell behavior, vascular growth and osteogenesis. The diversity scaffolds constructed were implanted in dog’s dorsal muscle and abdominal cavity to reveal the influence of both the architectural parameters of scaffolds and implantation sites on the ectopic bone formation in the scaffolds. The harvested results in animal experiments exhibited that the ectopic bone formation in HA scaffolds was significantly mediated by the pore diversity of scaffolds and similar in the two implantation sites. The tissue-engineered bone grafts in non-bony sites were applied to repair femoral defect of dogs.