Professor Jiang Chang, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Fellow of International Union of Societies for Biomaterials Science and Engineering (FBSE), Fellow of Royal Society of Chemistry (FRSC), Fellow of American Institute of Medical and Biological Engineering (AIMBE), and Fellow of Chinese Society for Biomaterials. Professor Chang is the vice president of the Interdisciplinary Research Society for Bone and Joint Injectable Biomaterials. His research focuses on bioactive materials for tissue regeneration and tissue engineering and the mechanisms of the interaction between biomaterials and cells. Professor Chang has over 500 scientific papers published in international peer-reviewed scientific journals with more than 30000 citations and H-index 104, and 70 patents.

Topic title: 3D-printed Bioactive Composite Hydrogel Scaffold for Vascularized Adipose Tissue Restoration

Abstract:

The increased number of mastectomies, combined with rising patient expectations for cosmetic and psychosocial outcomes, has necessitated the use of adipose tissue restoration techniques. In our study, bioactive composition for stimulating adipogenic differentiation of stem cells and angiogenesis was determined, and a bioactive composite hydrogel scaffold was prepared by three-dimensional (3D) printing technology, applying gelatin methacrylate anhydride (GelMA) as printing ink and calcium silicate (CS) bioceramic as an active ingredient for breast adipose tissue regeneration. The composite scaffold was found to promote vascularized adipose tissue restoration in vivo. These findings suggest that this 3D-printed bioactive composite scaffolds might be a good candidate for vascularized adipose tissue engineering and breast reconstruction.