王超，北京航空航天大学生物与医学工程学院，“医工百人”特聘副研究员，博士生导师，致力于基于生物力学及增材制造的颅颌面口腔疾病基础研究及临床转化工作。主持国家自然科学基金3项，主持国家外专局外国专家人才项目1项，参与科技部重点研发专项2项，相关科研成果已经在中国人民解放军总医院、北京大学口腔医院、武汉大学口腔医院、重庆医科大学附属口腔医院等三甲医院完成FIM临床试验。获教育部自然科学奖一等奖1项，中华口腔医学会科技奖三等奖1项，重庆市医学会科技奖一等奖1项。发表国际SCI论文70篇，授权专利15项，牵头/参与标准制定12项。担任国家自然科学基金通讯评审专家、中国医疗器械行业协会增材制造医疗器械专业委员会专家、中国生物材料学会材料生物力学分会委员/口腔颅颌面材料分会委员/生物材料先进制造分会委员、中国医学装备协会医用增材制造专业委员会委员等学术兼职。

Topic title：Research on the functional reconstruction of mandibular segmental defects

Abstract：

Mandibular segmental defects resulting from resection for traumas, benign or malignant neoplasms can lead to disturbances in mastication, swallowing, and phonation. The reconstruction of mandibular defects has always been a challenge in maxillofacial surgery. Over the past decades, many clinical solutions have been adopted for mandibular reconstruction; however, all of them have limitations or deficiencies in restoring facial aesthetics and oral functions. With the development of additive manufacturing techniques and computer technology, 3D-printed customized scaffolds, finite element analysis, and bone regeneration computer models provide a reliable theoretical basis and technical support for functional reconstruction in the mandible. This study proposes and validates a working framework for a novel 3D customized lattice-like scaffold for mandibular reconstruction based on biomechanical and mechanobiological approaches. Reconstructing mandibular segmental defects necessitates providing robust and scientifically grounded clinical foundations which can be achieved by offering novel insights into the design criteria for regenerative implants.