Invited Speaker



Update time:2024-02-26 12:02




Academic position: Member of the second Committee of Microsurgery Branch of Chinese Medical Doctor Association, Deputy Chairman of Digital and intelligent microsurgery Group of the second Committee of Microsurgery Branch of Chinese Medical Doctor Association, Deputy chairman (youth) of Orthopaedic Branch of Xinjiang Medical Association, Deputy chairman of the Council of Xinjiang Trauma Treatment Alliance, standing member of Trauma Surgery and First Aid Branch of Xinjiang Medical Association, Kashgar Regional Medical Association Chairman of Orthopedics Professional Committee, editorial member of the 11th Editorial Committee of Chinese Journal of Microsurgery, reviewer of Chinese Journal of Trauma and Orthopedics.

Presided over the sub-project of the autonomous region's major science and technology project "Construction and application of digital orthopedics center in Xinjiang", presided over the provincial and ministerial innovation team project "digital orthopedics innovation team", participated in the national key research and development project "Orthopedics robot application demonstration in remote areas" and other 12 scientific research projects. The first author and corresponding author have published more than 30 academic papers, including 12 SCI papers. He won the national Health system youth post expert, Kashgar Youth May Fourth Medal, Tianshan Talents of the Autonomous Region (the third period).

Topic title: 3D printed PLGA scaffold with nano-hydroxyapatite carrying linezolid for treatment of infected bone defects


Background: Linezolid has been reported to protect against chronic bone and joint infection. In this study, linezolid was loaded into the 3D printed poly (lactic-co-glycolic acid) (PLGA) scaffold with nano-hydroxyapatite (HA) to explore the effect of this composite scaffold on infected bone defect (IBD). Methods: PLGA scaffolds were produced using the 3D printing method. Drug release of linezolid was analyzed by elution and high-performance liquid chromatography assay. PLGA, PLGA-HA, and linezolid-loaded PLGA-HA scaffolds, were implanted into the defect site of a rabbit radius defect model. Micro-CT, H&E, and Masson staining, and immunohistochemistry were performed to analyze bone infection and bone healing. Evaluation of viable bacteria was performed. The cytocompatibility of 3D-printed composite scaffolds in vitro was detected using human bone marrow mesenchymal stem cells (BMSCs). Long-term safety of the scaffolds in rabbits was evaluated. Results: The linezolid-loaded PLGA-HA scaffolds exhibited a sustained release of linezolid and showed significant antibacterial effects. In the IBD rabbit models implanted with the scaffolds, the linezolid-loaded PLGA-HA scaffolds promoted bone healing and attenuated bone infection. The PLGA-HA scaffolds carrying linezolid upregulated the expression of osteogenic genes including collagen I, runt-related transcription factor 2, and osteocalcin. The linezolid-loaded PLGA-HA scaffolds promoted the proliferation and osteogenesis of BMSCs in vitro via the PI3K/AKT pathway. Moreover, the rabbits implanted with the linezolid-loaded scaffolds showed normal biochemical profiles and normal histology, which suggested the safety of the linezolid-loaded scaffolds. Conclusion: Overall, the linezolid-loaded PLGA-HA scaffolds fabricated by 3D printing exerts significant bone repair and anti-infection effects.

Congress has ended
Important Dates
Conference Dates
March 29-31, 2024
Deadline for Submission of Abstract

December 31, 2023

Still open for submission

Notification of Abstract Acceptance

January 15, 2024

January 25, 2024