Cai Lin, Ph.D. Chief surgeon; Doctor of Biomedical Engineering; Doctoral tutor of Wenzhou Medical University; Director of the Burn and Wound Center of the First Affiliated Hospital of Wenzhou Medical University; Director of the Clinical Research Center for Tissue Engineering Skin of Wenzhou Medical University; Core member of the Wound Repair and Regenerative Medicine Center of Wenzhou Medical University

Research Fields: Dr. Lin has been engaged in clinical practice and related research in the field of burn and wound repair for a long time. Presided over more than 20 projects, including "Zhihui Action" of China Association for Science and Technology, the key special project of Zhejiang Natural Science Foundation, etc. The exploratory research on AI (artificial intelligence) wound recognition technology has won the provincial "Spearhead and Leading goose" major project in 2023. Participated in the "973" and National Natural Science Foundation projects. Published more than 60 articles in several authoritative journals as the first or corresponding author, including 22 SCI papers, such as AFM (IF=19.924), Theranostics (IF=11.600), Chemical Engineering Journal (IF=16.744), and a few of which have been awarded the ESI Highly Cited Papers, Journal Annual Highlight Papers, etc. Participated in the editing of 8 monographs, 1 group standard, and applied for 29 patents, of which 7 invention patents and 12 utility model patents have been authorized. Received the third prize of Scientific and Technological progress of Zhejiang Province, the second prize of Medical and Health Science and Technology of Zhejiang Province, etc. Created "Baipisu" composite cream for burn wound and infected eczema. Originally carry out vacuum sealing drainage (VSD) technique systematically in the field of burn in China, and put forward the hypothesis of "biphasic blood flow regulation effect". A number of innovative achievements, such as "new bioglass material for wound repair" and "intelligent UV (ultraviolet) disinfection monitoring and management system", have been transformed into industrial applications. As a discipline leader, he led the Burn Surgery Department to rank 6th among the top 100 STEM specialties in China hospitals in terms of scientific and technological quantitative value. As a core member of the Department of Wound Repair, the team was awarded the first national key clinical specialty construction project in China, achieving a major breakthrough in the construction of wound repair discipline.

Academic Positions: Member of the Sixth Committee of Chinese Medical Association Burn Surgery Branch; Member of Bioceramics Branch of Chinese Biomaterials Society; Executive Director of Translational Medicine Industry Branch of National Health Industry Enterprise Management Association; Vice Chairman of Burn Surgery and Wound Repair Branch of Zhejiang Provincial Medical Association; Vice President of Trauma Surgery Branch of Zhejiang Provincial Physicians Association; Executive Deputy Director of Zhejiang Wound Repair and Translational Application Centre; Director of Wenzhou Medical Association Burn Surgery and Wound Repair Branch.

Specialities: Rescue and treatment of severe burns; Repair of various complex hard-to-heal wounds, such as diabetic foot ulcers, varicose vein ulcers of the lower limbs (old rotting feet), skin tumor ulcers, deep pressure sores, sinus tracts, and large-area necrotic fasciitis, etc.

Topic title: Lycopene attenuates ischemic-hypoxic injury in random skin flaps via the Nrf2/HO-1 signaling pathway

Abstract:

In plastic and reconstructive surgery, random skin flaps are commonly used to repair all types of wounds. However, one of the serious postoperative complications is necrosis of the distal portion of the flap, in which lack of blood flow and enhanced inflammation are important causes. Previous studies have shown that the powerful antioxidant lycopene (Lyc) attenuates renal injury by mitigating inflammation and apoptosis, which aroused our great interest in whether it could promote the survival of ischemic flaps. In the next steps of our work, we focused on analyzing the mechanism of Lyc after ischemic-hypoxic injury of skin flaps. The results showed that Lyc could improve the survival of random skin flaps by enhancing angiogenesis and attenuating oxidative stress, inflammation and apoptosis. All these should be attributed to the mediation and regulation of the Nrf2/HO-1 signaling pathway by Lyc, whereas the blocking effect of brusatol (Bru) on the pathway effectively inhibited the above advantages. In conclusion, our study sheds new light on the therapeutic potential and clinical application of Lyc as an enhancement of random skin flap viability.