Zhou Guangdong, professor and doctoral supervisor of the Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, executive deputy director of the National Engineering Research Center for Tissue Engineering, director of the Shanghai Key Laboratory of Tissue Engineering Research, chief scientist of the national Key R&D Project, principal investigator of a number of national 863 and 973 projects. He has made outstanding contributions in the core technologies of cartilage and bone regeneration as well as their clinical translation for 26 years, and has made outstanding contributions in the core technologies of cartilage and bone regeneration, regulation mechanism of tissue regeneration, biomimetic simulation of microenvironment, repair of large animal defects, clinical and industrial translation of regenerative technology, and other fields. He has achieved a series of clinical breakthrough in the regeneration and reconstruction of osteochondral defects and congenital deformities such as joints, ears, nose, turbinates, meibomian plates, trachea, cleft lip and palate, hemifacial atrophy, and has created a new treatment mode of living tissue regeneration and reconstruction. He has involved and launched 22 clinical transformation studies of various types of living tissue regeneration technology, and has completed more than 200 cases of osteochondral defect regeneration and deformity correction.

Topic title: Key technologies of bone and cartilage regeneration as well as their clinical translation

Abstract:

Bone and cartilage regeneration as well as its functional reconstruction is always a great challenge in clinic. Tissue engineering provides a new strategy for solving this challenge. During the past ten years, our group performed a series of researches and realized clinical translation of multiple bone and cartilage regeneration technologies. The main advances include: 1) To establish a novel chondrogenic induction system, which efficiently regulates cartilage regeneration of stem cells and dedifferentiated chondrocytes; 2) To establish a series of technological system of in vitro 3D cartilage regeneration and to realize accurate control of 3D shape and mechanical strength by means of 3D printing and bioreactors; 3) To repair successfully various bone and cartilage defect models in large animals; 4) To successfully perform multiple clinical trials of bone and cartilage regeneration as well as its functional reconstruction, such as reconstruction of external ear, repair and reconstruction of nasal cartilage defects, reconstruction of nasal turbinate, repair of tarsal plate defects, repair of articular cartilage defects as well as repair of articular osteochondral defects.