Innovative Personalized Precision Medical Devices Fabricated by Bioprinting and Its Clinical Translation Application

Bioprinting fabricates patient-specific precision medical devices. Key techniques include biomaterial screening, printing-parameter optimization, and functional design. A loofah-inspired hydroxyapatite bone scaffold uses composite bioink to address bioceramic brittleness and osteogenic activity. Digital-light-processing bioprinting constructs hollow channels with icariin-loaded GelMA hydrogel for sustained release. In vitro and rabbit models verify its promotion of osteogenesis, angiogenesis, and bone regeneration for personalized repair[1-3]. Bioprinting also enables customized cartilage implants for auricular reconstruction[4]. Clinical translation bottlenecks involve biocompatibility validation, mechanical performance, quality control, and standardization[5]. Applications cover tissue-repair implants, surgical aids, and prostheses. Improved bioinks, standards, and collaboration will accelerate clinical translation for individualized therapy.

Keywords: bioprinting, personalized medical device, precision medicine, clinical translation, biomaterial

References

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[3] Zhou C C, Song P, Gui X Y, et al. A 3D printed customized programmed specific biological function scaffold material for promoting bone tissue repair and regeneration and preparation method thereof[P]. China Patent: CN113262325A, 2021‑08‑17.

[4] Gui X Y, Peng Z Y, Song P, et al. 3D printing personalized polylactic acid scaffold compounded with GelMA autologous auricular cartilage fragments for auricle reconstruction[J]. Bio‑Design and Manufacturing, 2024, 7(4): 789‑804.

[5] Zhou C C*, Wang K F, Sun Y, et al. Biofabrication (3D Bioprinting) Laboratory at Sichuan University[J]. Bio‑Design and Manufacturing, 2021, 4(2):432‑439.