Physical Field-Driven Biomedical Systems:

From Optoelectronic Tweezers to Micro/Nano Robotics

Precise manipulation at the micro and nanoscale is opening new frontiers in biomedicine. In this talk, I will present our group's research on physical field-driven biomedical systems, organized around two major themes: light-driven control and magnetic-driven control. In the first part, I will introduce our optoelectronic tweezers (OET) platform, which exploits optically induced dielectrophoresis for non-contact, high-precision single-cell manipulation. I will highlight its application in high-throughput functional antibody discovery, significantly accelerating screening workflows for therapeutic targets including PD-L1 and UPAR. In the second part, I will present our magnetically driven systems, including micro/nano robots engineered for targeted drug delivery, programmable in vivo navigation, and minimally invasive intervention, as well as our capsule robot platform for autonomous gastrointestinal diagnostics and therapy, featuring wireless actuation, real-time sensing, and closed-loop control. Together, these platforms reflect a unified vision of harnessing physical fields — light and magnetism — to precisely control biological systems across scales, bridging fundamental physics with clinical translation.

Prof. Lin FENG is currently a Professor at the School of Mechanical Engineering, Beihang University. He earned his Doctor of Engineering degree from Nagoya University. He has been awarded numerous prestigious honors, including the Young Yangtze River Scholar of China, Outstanding Young Talent of Beijing Municipality, Beijing Science and Technology Rising Star, and Forbes China 30 Under 30 in Science and Innovation. Serving as the founder and Chairman of Micro/nano Robot (Beijing) Technology Co., Ltd., his primary research interests cover micro-nanorobots and optoelectronic manipulation technologies. Dr. Feng has presided over more than 20 national and provincial-level research projects. Representative projects include the National Key R&D Program, special project of Intelligent Robotics and the disruptive technology project under the National Key R&D Program. To date, Dr. Feng has published over 200 academic papers including more than 20 cover papers and holds more than 40 patents. He was also invited by Wiley, published a book titled “Optoelectronic Tweezers for Micro/Nano-Scale Manipulation.”