Innovation and application of key technologies for high-quality wound repair

Guided by the concept of "precise diagnosis and treatment of burn wounds", we have taken the lead in proposing the concept of precise wound repair, focusing on the "two basic points" of high-quality treatment of burn wounds (precise diagnosis and precise treatment of wounds), and have achieved the following representative results: (1) In response to the difficulty of traditional techniques in detecting complex and dynamically changing inflammatory states of wounds in vivo, dynamically, and accurately, we have created a ROS sensitive MRI probe that can monitor the level of wound inflammation in real-time, dynamically, and sensitively, and have achieved visualization, tracking, feedback, and precise diagnosis of the degree of wound inflammation. (2) To address the challenge of low precision and efficiency in existing inflammation interventions, a series of new technologies have been developed to precisely regulate key inflammatory mediators and immune cell polarization in wounds, significantly improving accuracy and efficiency, laying the foundation for maintaining the optimal inflammatory immune microenvironment in wounds. (3) In response to the challenges of tissue necrosis caused by insufficient vascularization of wounds, infection risk caused by delayed epithelialization, excessive scarring, and functional impairment, a progressive treatment strategy centered on promoting vascular reconstruction and epidermal regeneration was first proposed, achieving rapid vascularization, epithelial coverage, and functional healing with low scarring of wounds.

Deng Jun, Director of the Regenerative Medicine Center and Medical Laboratory Department at the Second Affiliated Hospital of Chongqing Medical University, Professor and Doctoral Supervisor, Visiting Professor at the Department of Plastic Surgery and Aesthetics at the First Affiliated Hospital of Chongqing Medical University, Chief Scientist (Youth) of the National Key R&D Program, National Excellent Youth (Outstanding A), Chongqing Academic and Technical Leader, and Chongqing Outstanding Youth. Hosted one key research and development project of the 14th Five Year Plan for Diagnosis and Treatment Equipment of the Ministry of Science and Technology, five projects funded by the National Natural Science Foundation of China, and one key project of the 173 Military Project; Mainly engaged in research on wound repair and tissue regeneration, as a corresponding or first author Science Translational Medicine、Science Advances、Nature Communications、Advanced Materials、Nano-Micro Letters、Advanced Functional Materials、Advanced Science、Biomaterials Published over 70 papers in journals, with a personal H-factor of 41; Obtained 9 national patents; Main (reference) compiled 5 books. Has won one first prize of the Chinese Medical Science and Technology Award, one first prize of the Chongqing Science and Technology Progress Award, one innovation award of the Wang Zhengguo Trauma Medicine Award, and one third prize of the Sichuan Provincial Science and Technology Progress Award. Served as an editorial board member of the Chinese Journal of Burn and Wound Repair, deputy editor in chief of the Journal of Plastic and Aesthetic Research, and deputy leader of the Stem Cell and Regenerative Medicine Group of the Wound Repair Professional Committee of the Chinese Medical Association.