3D打印与半月板软骨再生研究

Regeneration of Meniscus Cartilage Scaffold by 3D Printing

随着老龄化的出现，以及全民运动健身的推广，半月板退变和半月板损伤的患病率明显增加。半月板一旦损伤，无法自身修复，半月板的修复和再生一直是临床医生面临的难题。由于天然的、正常的半月板组成、结构、力学特点特殊，仿生制造非常困难，因此半月板的再生成为了医生、生物医学工程、增材制造领域研究的热点。本研究通过增材制造技术仿生打印半月板再生组织工程支架，并进行了生物医学体外研究和动物体内再生有效性试验，发现增材制造在半月板仿生制造方面有非常大的优势，同时也阐明3D打印在组织器官再生的生物制造方面有广泛的应用前景。

With the emergence of aging population and the promotion of national sports and fitness, the incidence of meniscus degeneration and meniscus injury has significantly increased. Once the meniscus is damaged, it cannot repair itself, and the repair and regeneration of the meniscus have always been a challenge faced by clinical doctors. Due to the unique composition, structure, and mechanical characteristics of natural and normal meniscus, biomimetic manufacturing is very difficult. Therefore, meniscus regeneration has become a hot topic in the fields of doctors, biomedical engineering, and additive manufacturing. This study used additive manufacturing technology to biomimetic print meniscus regeneration tissue engineering scaffolds, and conducted in vitro biomedical research and in vivo animal regeneration effectiveness experiments. It was found that additive manufacturing has great advantages in meniscus biomimetic manufacturing, and also clarified that 3D printing has broad application prospects in the biomanufacturing of tissue and organ regeneration.

解放军总医院主任医师、教授、博士研究生导师、国家骨科运动康复临床医学研究中心副主任。科技部“863”、“干细胞及转化研究”重点专项首席专家，“十三五”国家重点研发计划“增材制造与激光制造”和“生物医用材料研发与组织器官修复替代”专家组成员，“十四五”国家重点研发计划“数字诊疗与生物材料”专家组成员。中华医学会组织修复与再生分会副主任委员。以第一负责人承担科技部“863”、支撑计划、重点研发、国家自然基金面上和重点项目，发表SCI文章240余篇，获得全军科技进步一等奖、北京医学奖、黄家驷生物医学工程等奖项，2022年荣获第五届人民名医称号。

Chief Physician, Professor, and PhD Supervisor at the General Hospital of the People's Liberation Army, Deputy Director of the National Clinical Research Center for Orthopedics and Sports Medicine. Chief Expert of the Ministry of Science and Technology's "863 Program" and "Stem Cell and Translational Research" Key Special Project, member of the expert panels for the "Additive Manufacturing and Laser Manufacturing" and "Research and Development of Biomedical Materials and Tissue Organ Repair and Replacement" projects under the 13th Five-Year Plan National Key R&D Program, and member of the expert panel for the "Digital Diagnosis and Treatment and Biomedical Materials" project under the 14th Five-Year Plan National Key R&D Program. Deputy Director of the Organization Repair and Regeneration Branch of the Chinese Medical Association. As the primary leader, has undertaken projects under the Ministry of Science and Technology's "863 Program," Support Program, Key R&D Program, and National Natural Science Foundation General and Key Projects, published over 240 SCI articles, and received awards such as the First Prize for Scientific and Technological Progress of the PLA, Beijing Medical Award, Huang Jiashi Biomedical Engineering Award, and was honored with the title of "People's Famous Physician" in 2022.