Controlled Bioprinting Technology and Its Applications for Organoid-Laden Constructs

Organoids exhibit outstanding self-assembly capacity and can recapitulate the key structural and functional features of human tissues, rendering them highly promising biological units for tissue engineering, disease modeling and drug screening. Conventional fabrication methods suffer from insufficient spatial control, which hinders the precise patterning of organoid-laden microtissues. Controlled bioprinting provides an effective strategy for the spatial assembly of organoids within biomaterial constructs. This presentation will introduce explorations on high-throughput organoid fabrication, present two controlled bioprinting technologies together with their experimental results, and conclude with prospects for future technological development and translational potential.

Her research has long focused on biomanufacturing and biological additive manufacturing. She put forward an innovative modularassembly biological additive manufacturing process and developed multiprocess integrated biomanufacturing systems with inhouse biological CAD/CAM software. She has led dozens of research projects, including subtasks of the National Key R&D Program of China, projects funded by the National Natural Science Foundation of China, and key military research programs. Her publication record comprises over 80 peerreviewed papers, with more than 60 granted invention patents.